Structure of PDB 6bkj Chain B

Receptor sequence
>6bkjB (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICE
NPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIE
NYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEK
AYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIE
RGSLMGCSIDDGTRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWG
QVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKL
EICNLTA
3D structure
PDB6bkj Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q123 C129 H334 N358 W360
Catalytic site (residue number reindexed from 1) Q66 C72 H223 N247 W249
Enzyme Commision number 3.4.22.54: calpain-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G127 C129 G221 G222 H334 G70 C72 G164 G165 H223
BS02 CA B I113 D114 G115 N117 D120 E199 I56 D57 G58 N60 D63 E142
BS03 CA B E364 D371 T392 D394 E396 E253 D260 T281 D283 E285
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bkj, PDBe:6bkj, PDBj:6bkj
PDBsum6bkj
PubMed29382717
UniProtP20807|CAN3_HUMAN Calpain-3 (Gene Name=CAPN3)

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