Structure of PDB 6bjo Chain B

Receptor sequence
>6bjoB (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
VPGKVTLQKDAQNLIGISIGGGAYCPCLYIVQVFDNTPAALDGTVAAGDE
ITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKL
3D structure
PDB6bjo Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure.
ChainB
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUY B L32 I33 G34 I35 F53 K83 A87 L14 I15 G16 I17 F34 K64 A68 MOAD: ic50=513nM
PDBbind-CN: -logKd/Ki=6.29,IC50=0.51uM
External links
PDB RCSB:6bjo, PDBe:6bjo, PDBj:6bjo
PDBsum6bjo
PubMed29280296
UniProtQ9NRD5|PICK1_HUMAN PRKCA-binding protein (Gene Name=PICK1)

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