Structure of PDB 6bir Chain B

Receptor sequence
>6birB (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]
DTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVT
ELGRPSAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVYPEVTV
YPAKTQPHNLLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWT
FQTLVMLETVPRSGEVYTCQVEHPSLTSPLTVEWRA
3D structure
PDB6bir The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H13 Y30 Y47 S57 Y60 W61 L67 Q70 R71 A74 Y78 H81 N82 V85 H12 Y29 Y46 S56 Y59 W60 L66 Q69 R70 A73 Y77 H80 N81 V84
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6bir, PDBe:6bir, PDBj:6bir
PDBsum6bir
PubMed29317506
UniProtP01911|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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