Structure of PDB 6bic Chain B

Receptor sequence
>6bicB (length=164) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HHAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTVKEFFGEPLSSIAI
HQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAV
RMGAIASMRIQGRLVHGQSGMLLGTIPGDCGAPYVHKRGNDWVVCGVHAA
ATKSGNTVVCAVQA
3D structure
PDB6bic Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5LH B H30 I109 Q110 T134 I135 C139 H157 A158 A160 T161 H32 I110 Q111 T125 I126 C130 H148 A149 A151 T152
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bic, PDBe:6bic, PDBj:6bic
PDBsum6bic
PubMed30883881
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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