Structure of PDB 6be6 Chain B

Receptor sequence
>6be6B (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
EKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRQ
ISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYV
FTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQN
YGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIM
YARATSGDKLNNNKFSLCSIRQISQVLEKKRNNCFVESGQPICGNGMVEQ
GEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAF
KSKSEKCRDDSDCAREGICNGFTALCPASDPKPQFTDCNRHTQVCINGQC
AGSICEKYGLEECTCAKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTI
TLQPGSPCNDFRGYCDVFMRCRLVDADGPLG
3D structure
PDB6be6 Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.81: ADAM10 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B G353 K354 G136 K137
BS02 ZN B H383 H387 H393 H166 H170 H176
BS03 CA B I459 C460 N462 M464 E466 E469 D472 I242 C243 N245 M247 E249 E252 D255
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6be6, PDBe:6be6, PDBj:6be6
PDBsum6be6
PubMed29224781
UniProtO14672|ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (Gene Name=ADAM10)

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