Structure of PDB 6b9o Chain B

Receptor sequence
>6b9oB (length=937) Species: 3823 (Canavalia ensiformis) [Search protein sequence]
MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVEN
VLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELVRKLVKAGQLE
FVNGGWCMHDEATTHYIDMIDHTTLGHRFIQEQFNKIPRAGWQIDPFGHS
AVQGYLLGAELGFDSVHFARIDYQDREKRKAEKSLEVVWRGSKTFGSSAQ
IFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFIDAAL
TQAKITRTNHIMWTMGDDFQYQYAESWFKQMDKLIHHVNKDGRVNALYST
PSIYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRSALKDYVRML
SGYYLATRQLGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTND
YAKRLAIGASKAEAVVSSSLACLTSKCSAPASAFSQCHLFNISYCPPTES
SIPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEM
DDVTANLRSFYVKAYEGEVPKDADVYWSLFKASVPPLGWSTYFISELNIG
PGDLKMSFSSLTGQLKRMYNSKTGVDIPIQQNYLWYESSEGDFSDYQASG
AYIFRPNGQPPPHRSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHA
EIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYR
EDWPLEVTQPVAGNYYPLNLGIYTKDEKSEFSVLVDRATGGASIKDGEVE
LMLHRRTIRDDGRGVGEPLDEQVCMEYTCEGLTVRGNYYLSIHKPAAGSR
WRRTTGQEIYSPMLLAFTQENMENWKSSHSTKGIYMDPNYSLPPSVALIT
LEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKIEELREVSL
SANQEKSEMKKMKWSVEGDDFVVELGPMEIRTFLLQF
3D structure
PDB6b9o Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition.
ChainB
Resolution1.841 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.24: alpha-mannosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B F234 D235 F234 D235
BS02 BMA B A402 K403 Y520 A402 K403 Y515
BS03 MAN B Y520 E521 Y515 E516
BS04 MAN B F374 K403 F374 K403
BS05 MAN B V799 C800 V773 C774
BS06 MAN B K518 G522 M801 K513 G517 M775
BS07 MAN B H396 N399 H396 N399
BS08 MAN B Q34 H396 D400 K403 Q34 H396 D400 K403
BS09 ZN B H23 D25 D145 H386 H23 D25 D145 H386
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004559 alpha-mannosidase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
Cellular Component
GO:0000326 protein storage vacuole
GO:0005773 vacuole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6b9o, PDBe:6b9o, PDBj:6b9o
PDBsum6b9o
PubMed29722924
UniProtC0HJB3|MANA_CANEN Alpha-mannosidase

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