Structure of PDB 6b9l Chain B

Receptor sequence
>6b9lB (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
KEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKK
3D structure
PDB6b9l Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E40 L54 M55 Q56 N57 M59 Y65 M66 C70 T101 R103 S107 F108 F156 R159 V161 C188 V189 L192 E14 L28 M29 Q30 N31 M33 Y39 M40 C44 T75 R77 S81 F82 F130 R133 V135 C162 V163 L166
External links
PDB RCSB:6b9l, PDBe:6b9l, PDBj:6b9l
PDBsum6b9l
PubMed30110533
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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