Structure of PDB 6b77 Chain B

Receptor sequence
>6b77B (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPED
LTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDAD
GSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEA
QVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQ
AAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
3D structure
PDB6b77 Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
ChainB
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H40 D89 Q188 G189 D190 S191
Enzyme Commision number 3.4.21.38: coagulation factor XIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B C122 Q204 A205 E205B R205C R206 C114 Q200 A201 E203 R204 R205
BS02 CWV B H57 D189 A190 C191 Q192 G193 S195 W215 G216 G219 H40 D185 A186 C187 Q188 G189 S191 W214 G215 G217
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6b77, PDBe:6b77, PDBj:6b77
PDBsum6b77
PubMed29519898
UniProtP00748|FA12_HUMAN Coagulation factor XII (Gene Name=F12)

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