Structure of PDB 6b6w Chain B

Receptor sequence

>6b6wB (length=628) Species: 881 (Nitratidesulfovibrio vulgaris)

SSSKTIRSRSIWDDAHAMLEKAKAEGISTVWDRAAEQTPACKFCELGTTC
RNCIMGPCRIANRKDGKMRLGVCGADADVIVARNFGRFIAGGAAGHSDHG
RDLIETLEAVAEGKAPGYTIRDVAKLRRIAAELGVADAATRPAHDVAADL
VTICYNDFGSRRNALAFLARAPQVRRDLWQRLGMTPRGVDREIAEMMHRT
HMGCDNDHTSLLVHAARTALADGWGGSMIGTELSDILFGTPRPRQSTVNL
GVLRKDAVNILVHGHNPVVSEMILAATREPAVRQAAQDAGAADINVAGLC
CTGNELLMRQGIPMAGNHLMTELAIVTGAADAIVADYQCIMPSLVQIAAC
YHTRFVTTSPKGRFTGATHVEVHPHNAQERCREIVMLAIDAYTRRDPARV
DIPSQPVSIMSGFSNEAILEALGGTPKPLIDAVVAGQIRGFVGIVGCNNP
KIRQDSANVTLTRELIRRDIMVLATGCVTTAAGKAGLLVPEAASKAGEGL
AAVCRSLGVPPVLHMGSCVDNSRILQLCALLATTLGVDISDLPVGASSPE
WYSEKAAAIAMYAVASGIPTHLGLPPNILGSENVTAMALHGLQDVVGAAF
MVEPDPVKAADMLEAHIVARRARLGLTS

3D structure

• PDB: 6b6w Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase.
• Chain: B
• Resolution: 1.72 Å

Enzymatic activity

• Enzyme Commision number: 1.2.7.4: anaerobic carbon-monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FES	B	C42 C45 T50 R60	C41 C44 T49 R59
BS02	SF4	B	C51 C54 G57 C59 V73 C74 R84 M203	C50 C53 G56 C58 V72 C73 R83 M202
BS03	XCC	B	H266 C301 C302 H319 C340 C448 C478 C519 Y553 S554 K556	H265 C300 C301 H318 C339 C447 C477 C518 Y552 S553 K555
BS04	CUV	B	H266 C301 C302 C340 G447 C448 G477 C478 C519 S554 K556	H265 C300 C301 C339 G446 C447 G476 C477 C518 S553 K555

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004601 peroxidase activity
• GO:0016151 nickel cation binding
• GO:0016491 oxidoreductase activity
• GO:0043885 anaerobic carbon-monoxide dehydrogenase activity
• GO:0046872 metal ion binding
• GO:0050418 hydroxylamine reductase activity
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006091 generation of precursor metabolites and energy
• GO:0042542 response to hydrogen peroxide
• GO:0098869 cellular oxidant detoxification

External links

• PDB: RCSB:6b6w, PDBe:6b6w, PDBj:6b6w
• PDBsum: 6b6w
• PubMed: 30277213
• UniProt: Q72A99