Structure of PDB 6b62 Chain B

Receptor sequence

>6b62B (length=252) Species: 224325 (Archaeoglobus fulgidus DSM 4304)

MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAE
DAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVS
LCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYC
NAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYD
AAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLEL
IK

3D structure

• PDB: 6b62 Osmolyte binding capacity of a dual action IMPase/FBPase (AF2372)
• Chain: B
• Resolution: 2.003 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E67 D82 L84 D85 T87 D200
• Catalytic site (residue number reindexed from 1): E67 D82 L84 D85 T87 D200
• Enzyme Commision number: 3.1.3.11: fructose-bisphosphatase.
  3.1.3.25: inositol-phosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLU	B	N151 K164 R165	N151 K164 R165
BS02	GLU	B	G93 P95 Y97 A121	G93 P95 Y97 A121
BS03	GLU	B	G15 Y118 E125	G15 Y118 E125
BS04	GLU	B	R18 L120 T122	R18 L120 T122
BS05	MG	B	D38 T40 P41 E67 E68	D38 T40 P41 E67 E68
BS06	MG	B	E67 D82 L84	E67 D82 L84

Gene Ontology

Molecular Function

• GO:0008934 inositol monophosphate 1-phosphatase activity
• GO:0016787 hydrolase activity
• GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
• GO:0046872 metal ion binding
• GO:0052832 inositol monophosphate 3-phosphatase activity
• GO:0052833 inositol monophosphate 4-phosphatase activity
• GO:0052834 inositol monophosphate phosphatase activity

Biological Process

• GO:0006020 inositol metabolic process
• GO:0007165 signal transduction
• GO:0046854 phosphatidylinositol phosphate biosynthetic process

External links

• PDB: RCSB:6b62, PDBe:6b62, PDBj:6b62
• PDBsum: 6b62
• UniProt: O30298|BSUHB_ARCFU Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (Gene Name=suhB)