Structure of PDB 6b4o Chain B

Receptor sequence
>6b4oB (length=448) Species: 226185 (Enterococcus faecalis V583) [Search protein sequence]
KTYDYIVIGGGSGGIASANRAGMHGANVLLIEGNEIGGTCVNVGCVPKKV
MWQASSMMEMMERDTAGYGFDVEIKNFSFKQLVENREKYIDFLHGAYNRG
LDSNNIERIHGYATFTGEQTIEVNGTEYTAPHILIATGGRPKKLGIPGEE
YALDSNGFFALEEMPKRVVFVGAGYIAAELAGTLHGLGAETHWAFRHERP
LRSFDDMLSEKVVERYQEMGMQIHPNATPAKIEKTAQNEYVITFENGESI
TTDAVIFGTGRQPNTDQLGLENTKVALDEKGYVKVDKFQNTTQNGIYAVG
DVIGKIDLTPVAIAAGRRLSERLFNGQTDLYLDYNLVPTVVFTHPPVATI
GLTEKAALEEYGEDQVKIYRSSFTPMYFALGEYRQKCDMKLICVGKEEKI
VGLHGIGIGVDEMLQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
3D structure
PDB6b4o 1.73 Angstrom Resolution Crystal Structure of Glutathione Reductase from Enterococcus faecalis in Complex with FAD.
ChainB
Resolution1.73 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I37 C41 C46 K49 Y176 E180 A436 H438 E443
Catalytic site (residue number reindexed from 1) I36 C40 C45 K48 Y175 E179 A435 H437 E442
Enzyme Commision number 1.8.1.7'
'3.3.1.1
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B I9 G12 S13 G14 E33 G34 T40 C41 G45 C46 K49 Y113 A114 T138 Y176 I177 R262 G301 D302 D308 L309 T310 I8 G11 S12 G13 E32 G33 T39 C40 G44 C45 K48 Y112 A113 T137 Y175 I176 R261 G300 D301 D307 L308 T309
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6b4o, PDBe:6b4o, PDBj:6b4o
PDBsum6b4o
PubMed
UniProtQ82Z09

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