Structure of PDB 6b16 Chain B

Receptor sequence
>6b16B (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQ
QQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTD
VVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVK
LTDFGEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGE
PPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGS
AKELLQHQFLKIAKPLSSLTPLIAAAKEATK
3D structure
PDB6b16 Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
ChainB
Resolution2.285 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 T427
Catalytic site (residue number reindexed from 1) N135 K137 D139 N140 D153 T166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C7Y B A297 Y346 L347 G350 D393 N394 L396 T406 A43 Y92 L93 G96 D139 N140 L142 T152 MOAD: Ki=32nM
BindingDB: Ki=32nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6b16, PDBe:6b16, PDBj:6b16
PDBsum6b16
PubMed27346791
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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