Structure of PDB 6b0y Chain B

Receptor sequence
>6b0yB (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETS
LLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIK
RVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQG
VDDAFYTLVREIRKHKE
3D structure
PDB6b0y The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors.
ChainB
Resolution1.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8ZG B G10 C12 K16 P34 A59 G60 Q61 E62 R68 M72 Y96 Q99 G9 C11 K15 P33 A58 G59 Q60 E61 R67 M71 Y95 Q98
BS02 GDP B G13 V14 G15 K16 S17 A18 F28 D30 E31 N116 K117 D119 S145 A146 K147 G12 V13 G14 K15 S16 A17 F27 D29 E30 N115 K116 D118 S144 A145 K146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6b0y, PDBe:6b0y, PDBj:6b0y
PDBsum6b0y
PubMed29760531
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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