Structure of PDB 6b0f Chain B

Receptor sequence
>6b0fB (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDMVEIFDML
LATSSRFRMMNLQGEEFVCLKSIILLNSGEEKDHIHRVLDKITDTLIHLM
AKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHL
3D structure
PDB6b0f Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.
ChainB
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C6V B M343 T347 E353 F404 M421 G521 M27 T31 E37 F85 M93 G181 BindingDB: IC50=6.0nM
External links
PDB RCSB:6b0f, PDBe:6b0f, PDBj:6b0f
PDBsum6b0f
PubMed29562737
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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