Structure of PDB 6ayw Chain B

Receptor sequence
>6aywB (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
CTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQ
KLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE
YYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLA
DFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYI
LLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN
PAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRK
3D structure
PDB6ayw The structure of human CamKII with bound inhibitor
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D136 K138 E140 N141 D157 T177
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D151 T171
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2V B L20 G21 V28 A41 F90 L92 V93 N141 L143 D157 L14 G15 V22 A35 F84 L86 V87 N135 L137 D151 BindingDB: IC50=37nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ayw, PDBe:6ayw, PDBj:6ayw
PDBsum6ayw
PubMed
UniProtQ13557|KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit delta (Gene Name=CAMK2D)

[Back to BioLiP]