Structure of PDB 6as5 Chain B

Receptor sequence
>6as5B (length=267) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
LRAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKPAARNALR
DTPLDPERTVVRINAGGTADQARDLEALAGTAYTTVMLPKAESAAQVIEL
APRDVIALVETARGAVCAAEIAAADPTVGMMWGAEDLIATLGGSSSRRAD
GAYRDVARHVRSTILLAASAFGRLALDAVHLDILDVEGLQEEARDAAAVG
FDVTVCIHPSQIPVVRKAYRPSHEKLAWARRVLAASRSERGAFAFEGQMV
DSPVLTHAETMLRRAGE
3D structure
PDB6as5 An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism.
ChainB
Resolution2.035 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B E120 D146 E110 D136
BS02 COA B F20 C21 P22 R28 K31 R72 I217 H218 P219 F10 C11 P12 R18 K21 R62 I207 H208 P209
BS03 AAE B R72 L118 E120 G143 E145 D146 R62 L108 E110 G133 E135 D136
BS04 COA B A252 M259 A242 M249
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006107 oxaloacetate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6as5, PDBe:6as5, PDBj:6as5
PDBsum6as5
PubMed31320588
UniProtP9WPE1|CITEL_MYCTU Citrate lyase subunit beta-like protein (Gene Name=citE)

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