Structure of PDB 6are Chain B

Receptor sequence
>6areB (length=397) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
GMSSLPAVYIVSSARTPVGSFLGSLSSLTAPQLGAHAIKAALAKVDGLKP
SDVQEVFFGNVISANVGQNPARQCALGAGLEESTICTTVNKVCASGLKAI
ILGAQTIMTGNADVVVAGGTESMSNAPHYLPNLRTGAKYGHQSLVDGIMK
DGLTDAGKQELMGLQAEECAQDHGFSREQQDEYAIRTYEKAQAAQKAGLF
DEEIAPIQLPGFKPDVTVTQDEEPKNLNPEKLRAIKPAFIPGSGTVTAPN
SSPLNDGAAAVVLVSEAKLKELNLKPVAKILGWGDAAQQPSKFTTAPALA
IPKALKHAGVGQDAIDAFEINEAFSVVALANMKLLGIPEEKVNLHGGAVA
IGHPIGASGARILTTLLGVLKAKKGKLGCAGICNGGGGASALVVELL
3D structure
PDB6are Structure of Aspergillus fumigatus Cytosolic Thiolase: Trapped Tetrahedral Reaction Intermediates and Activation by Monovalent Cations
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C92 H354 C384 G386
Catalytic site (residue number reindexed from 1) C93 H353 C383 G385
Enzyme Commision number 2.3.1.9: acetyl-CoA C-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B C92 L152 M161 Y187 N227 N229 K232 L233 I236 A249 P250 S253 A324 H354 C93 L153 M162 Y188 N226 N228 K231 L232 I235 A248 P249 S252 A323 H353
Gene Ontology
Molecular Function
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0006696 ergosterol biosynthetic process
GO:0016126 sterol biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6are, PDBe:6are, PDBj:6are
PDBsum6are
PubMed
UniProtQ4WCL5|ER10B_ASPFU Acetyl-CoA acetyltransferase erg10B, cytosolic (Gene Name=erg10B)

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