Structure of PDB 6aj8 Chain B

Receptor sequence
>6aj8B (length=413) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
SNKISATGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRD
KTEDRVTVEAAYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIR
TILGGTVFREPIICSNVPRLVTTWKKPVVIGRHAFGDQYSATDAVVKEPG
TFEMRFIPANGGEPKVYKVFDYKSGGVMMGMYNTDDSIRDFARSCFEFAL
ARKWPLYLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYEHRLI
DDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGK
TVEVEAAHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNT
LLEFTQRLEDVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAV
SQRLKVAMQKSKV
3D structure
PDB6aj8 Biochemical characterization of a novel Trypanosoma brucei glycosomal isocitrate dehydrogenase with dual coenzyme specificity (NADP+/NAD+)
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D274 D278 D274 D278
BS02 NAP B T75 I76 T77 N96 H308 G309 T310 V311 T312 H314 T326 N327 T75 I76 T77 N96 H308 G309 T310 V311 T312 H314 T326 N327
BS03 AKG B R100 R132 R100 R132
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006739 NADP metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aj8, PDBe:6aj8, PDBj:6aj8
PDBsum6aj8
PubMed
UniProtQ387G0

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