Structure of PDB 6aip Chain B

Receptor sequence
>6aipB (length=310) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TEEEQYFKTNPKPAYIDELIKDAKEFIDLQYSLKRNKIVLITSGGTTVPL
ENNTVRFIDNFSAGTRGASSAEQFLANGYSVIFLHREFSLTPYNRSFSHS
INTLFLDYIDSEGKIKPEFAENVLKNKKLYDKYMEKEEKLLLLPFTTVNQ
YLWSLKSIAKLLNNSGCLFYLAAAVSDFFVPYSRLPQHKIQEGTTRTTPD
GKLIVNLDPVPKFLRRLVESWATQAMIVSFKLETDESMLLYKCTQALDRY
NHQLVIGNLLQTRNKQVIFVSPENRKGDWVRLDEKHASIEEMIIPEVIAR
HDKWVAHSKT
3D structure
PDB6aip Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
ChainB
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.5: phosphopantothenate--cysteine ligase (CTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9Z6 B S99 A100 G101 T102 R103 A209 A210 A211 K262 F263 L264 F280 L282 N308 R313 S62 A63 G64 T65 R66 A172 A173 A174 K212 F213 L214 F230 L232 N258 R263
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004632 phosphopantothenate--cysteine ligase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990143 CoA-synthesizing protein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6aip, PDBe:6aip, PDBj:6aip
PDBsum6aip
PubMed30653991
UniProtP40506|PPCS_YEAST Phosphopantothenate--cysteine ligase CAB2 (Gene Name=CAB2)

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