Structure of PDB 6ahi Chain B

Receptor sequence
>6ahiB (length=306) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
MMIITTMQDAIGRTPVFKFTNKDYPIPLNSAIYAKLEHLNPGGSVKDRLG
QYLIGEGFKTGKITSKTTIIEPTAGNTGIALALVAIKHHLKTIFVVPEKF
STEKQQIMRALGALVINTPTSEGISGAIKKSKELAESIPDSYLPLQFENP
DNPAAYYHTLAPEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIR
LIGVEPEGSILNGGEPGPHEIEGIGVEFIPPFFENLDIDGFETISDEEGF
SYTRKLAKKNGLLVGSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRYL
SKGIYL
3D structure
PDB6ahi Identification and characterization of Helicobacter pylori O-acetylserine-dependent cystathionine beta-synthase, a distinct member of the PLP-II family.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K46 S267
Catalytic site (residue number reindexed from 1) K46 S267
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MET B X46 T73 A74 G75 N76 T77 K104 X46 T73 A74 G75 N76 T77 K104 PDBbind-CN: -logKd/Ki=3.60,Kd=252uM
Gene Ontology
Molecular Function
GO:0004122 cystathionine beta-synthase activity
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ahi, PDBe:6ahi, PDBj:6ahi
PDBsum6ahi
PubMed31132312
UniProtP56067|CYSM_HELPY Cysteine synthase (Gene Name=cysM)

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