Structure of PDB 6ah4 Chain B

Receptor sequence
>6ah4B (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
FFTYETPKVIVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAI
ESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGF
CPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTE
VDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFH
PDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQC
IPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFD
VLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAK
KFEEVNE
3D structure
PDB6ah4 Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.
ChainB
Resolution3.296 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC B D250 K315 D244 K309
BS02 ATP B D158 S275 N279 R281 K299 D152 S269 N273 R275 K293 BindingDB: EC50=340nM
BS03 ATP B K63 K65 T172 F174 M200 K57 K59 T166 F168 M194 BindingDB: EC50=340nM
Gene Ontology
Molecular Function
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
GO:0005216 monoatomic ion channel activity
GO:0005524 ATP binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0033198 response to ATP
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6ah4, PDBe:6ah4, PDBj:6ah4
PDBsum6ah4
PubMed31232692
UniProtP56373|P2RX3_HUMAN P2X purinoceptor 3 (Gene Name=P2RX3)

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