Structure of PDB 6ago Chain B

Receptor sequence
>6agoB (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
KYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSG
YEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQR
HEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIE
QYSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIG
LYALKDMPAGTELTYDCKCGFEKC
3D structure
PDB6ago Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop.
ChainB
Resolution3.103 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C2270 C2275 C219 C224
BS02 ZN B C2091 C2104 C2108 C56 C69 C73
BS03 ZN B C2117 C2122 C82 C87
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6ago, PDBe:6ago, PDBj:6ago
PDBsum6ago
PubMed30827841
UniProtQ9NR48|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)

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