Structure of PDB 6aaj Chain B

Receptor sequence
>6aajB (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHLRDFER
EIEILKSLQHDNIVKYKGVCNLKLIMEYLPYGSLRDYLQAHAERIDHIKL
LQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQ
DKEYYKVKGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSK
SPPAEFMRMIGNDGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWN
NNVNQRPSFRDLALRVDQIRDNMA
3D structure
PDB6aaj Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
ChainB
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D976 R980 N981 D994
Catalytic site (residue number reindexed from 1) D123 R127 N128 D141
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9T6 B A880 L932 L983 A38 L79 L130 BindingDB: IC50=5.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6aaj, PDBe:6aaj, PDBj:6aaj
PDBsum6aaj
PubMed30145050
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

[Back to BioLiP]