Structure of PDB 6a94 Chain B

Receptor sequence
>6a94B (length=359) Species: 562,9606 [Search protein sequence]
QEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADM
LLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISL
DRYVAIQNPSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCL
LADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDN
LKVIEKADNAAQVKDALTKMRAAALDAGGDILVGQIDDALKLANEGKVKE
AQAAAEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFIT
NIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFS
RYIQCQYKE
3D structure
PDB6a94 Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOT B D155 V156 S159 L229 V235 G238 S242 W336 F339 F340 V366 D84 V85 S88 L151 V157 G160 S164 W294 F297 F298 V324
BS02 CLR B I86 Y394 Y399 I15 Y352 Y357
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6a94, PDBe:6a94, PDBj:6a94
PDBsum6a94
PubMed30723326
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28223|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)

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