Structure of PDB 6a8o Chain B

Receptor sequence
>6a8oB (length=236) Species: 10090 (Mus musculus) [Search protein sequence]
IVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIP
YPDVWRIYGGILSLSEITKETPSSRIKELIIHQEYKVSEGNYDIALIKLQ
TPLNYTEFQKPISLPSKADTNTIYTNCWVTGWGYTKEQGETQNILQKATI
PLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGRW
QLVGITSWGEGCARKDQPGVYTKVSEYMDWILEKTQ
3D structure
PDB6a8o Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.
ChainB
Resolution2.77 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H44 D93 K185 G186 D187 S188
Enzyme Commision number 3.4.21.34: plasma kallikrein.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B L41 T151 K192 S195 W215 G216 L28 T141 K185 S188 W208 G209
BS02 MRZ B D189 A190 T213 W215 G216 G219 D182 A183 T206 W208 G209 G211
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6a8o, PDBe:6a8o, PDBj:6a8o
PDBsum6a8o
PubMed30019481
UniProtP26262|KLKB1_MOUSE Plasma kallikrein (Gene Name=Klkb1)

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