Structure of PDB 6a8n Chain B

Receptor sequence
>6a8nB (length=245) Species: 10090 (Mus musculus) [Search protein sequence]
IVGGEFTEVENQPWFAAIYQKNKSPPSFKCGGSLISPCWVASAAHCFIQL
PKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALL
KIRTSTGQCAQPSRSIQTIALPPRFTDAPFGSDCEITGFGKESESDYLYP
KNLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGP
LICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIG
3D structure
PDB6a8n Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
ChainB
Resolution2.489 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H45 D96 K194 G195 D196 S197 G198
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K41 H57 E96 S97A L97B A98 Y99 Y151 D189 S190 K192 S195 W215 G216 R217 G218 K29 H45 E88 S90 L91 A92 Y93 Y149 D191 S192 K194 S197 W217 G218 R219 G220
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6a8n, PDBe:6a8n, PDBj:6a8n
PDBsum6a8n
PubMed30707839
UniProtP06869|UROK_MOUSE Urokinase-type plasminogen activator (Gene Name=Plau)

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