Structure of PDB 6a8g Chain B

Receptor sequence
>6a8gB (length=244) Species: 10090 (Mus musculus) [Search protein sequence]
IVGGEFTEVENQPWFAAIYQKNSPPSFKCGGSLISPCWVASAAHCFIQLP
KKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLK
IRTSTGQCAQPSRSIQTIALPPRFTDAPFGSDCEITGFGKESESDYLYPK
NLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGPL
ICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIG
3D structure
PDB6a8g Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
ChainB
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H44 D95 K193 G194 D195 S196 G197
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K41 H57 E96 S97A L97B Y99 Y151 D189 S190 C191 K192 S195 W215 G216 R217 G218 K28 H44 E87 S89 L90 Y92 Y148 D190 S191 C192 K193 S196 W216 G217 R218 G219
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6a8g, PDBe:6a8g, PDBj:6a8g
PDBsum6a8g
PubMed30707839
UniProtP06869|UROK_MOUSE Urokinase-type plasminogen activator (Gene Name=Plau)

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