Structure of PDB 6a4j Chain B

Receptor sequence
>6a4jB (length=338) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYPEKIIWD
IGGIAPKPCHEILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEA
GEIYTSKAVIIAIGAGIINPKQLDVKGVERYQLTNLHYVVQSYRRFKDKD
VLISGGGNTALDWAHDIAKIAKSVTVVYRKEDVSGHEAMKTLVTDLNVKL
CPKTRIKYLVETHISEVVLEHVESGDRHTVKFDDVIISHGFDRCNTLLSE
TSLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAFSDGANA
ANLAKTYIQPDANAEGYVSSHHEVFKEANKTIVNKHLY
3D structure
PDB6a4j Elucidation of the mechanism of disulfide exchange between staphylococcal thioredoxin2 and thioredoxin reductase2: A structural insight.
ChainB
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q141 S142
Catalytic site (residue number reindexed from 1) Q141 S142
Enzyme Commision number 1.18.1.2: ferredoxin--NADP(+) reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B V324 S325 S326 V318 S319 S320
BS02 FAD B P11 S12 D31 V32 Q33 G38 K39 I42 Y43 I48 D50 V83 I113 G114 G116 I117 I118 D285 L295 I296 P11 S12 D31 V32 Q33 G38 K39 I42 Y43 I48 D50 V83 I113 G114 G116 I117 I118 D279 L289 I290
Gene Ontology
Molecular Function
GO:0004324 ferredoxin-NADP+ reductase activity
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification

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Molecular Function
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Biological Process
External links
PDB RCSB:6a4j, PDBe:6a4j, PDBj:6a4j
PDBsum6a4j
PubMed30710560
UniProtQ2FVP8|FENR_STAA8 Ferredoxin--NADP reductase (Gene Name=SAOUHSC_02654)

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