Structure of PDB 6a46 Chain B

Receptor sequence
>6a46B (length=213) Species: 10090 (Mus musculus) [Search protein sequence]
EPPRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSLVLP
RVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGF
LSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGL
DRAHRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELLAWA
DEQARSWAHIEPM
3D structure
PDB6a46 Structural insights into the duplex DNA processing of TREX2
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DCM B D14 E16 A17 G19 L20 K73 Y122 D12 E14 A15 G17 L18 K69 Y118
BS02 MG B D14 E16 D193 D12 E14 D181
BS03 CA B N94 G95 A96 N90 G91 A92
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6a46, PDBe:6a46, PDBj:6a46
PDBsum6a46
PubMed30357414
UniProtQ9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)

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