Structure of PDB 6a04 Chain B

Receptor sequence
>6a04B (length=182) Species: 9823 (Sus scrofa) [Search protein sequence]
ANFNVAHGLAWSYYIGYLRLILPGLRARIQAYNQRHKNVLGGIGNHRLHI
LFPLDCGVPDDLSVADPNIRFLHELPQQGRVYTNSIYELLENGQPAGVCV
LEYATPLQTLFAMSQDGRAGFSREDRLEQAKLFCRTLEDILADAPEAQNN
CRLIVYQEPTEGGSFSLSQEILRHLRQEEREV
3D structure
PDB6a04 Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E B S162 Y163 Y167 R238 Y240 T263 S12 Y13 Y17 R80 Y82 T105 MOAD: Kd~6uM
PDBbind-CN: -logKd/Ki=5.21,Kd=6.18uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6a04, PDBe:6a04, PDBj:6a04
PDBsum6a04
PubMed31167783
UniProtB8XX90|STING_PIG Stimulator of interferon genes protein (Gene Name=STING1)

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