Structure of PDB 5zvh Chain B

Receptor sequence
>5zvhB (length=384) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
YLEAFPKELREYYKNLFGKEEANKIMKKLREPVEHYYIRVNTLKISREKL
IGELKKEGLKPLRSPYLPEGLYFVREGPNFSDDFEPKLPVVVANKYAAES
VYQGAMLYAPGVLKADKNIKEGDEVQIRDPKGLLVGIGIARMDYKEMTEA
TRGLAVEVTLPKFKLPSLSELKAFEKGYFYPQGLPSMVTARVLEPKEDDV
IIDMAAAPGGKTTHIAQLLENKGEIIAIDKSKNRLRKMEENIKRLGVKNV
KLVQMDARKLPDLGIKADKILLDAPCTALGVRPKLWEERTLKHIEATARY
QRAFIWAAIKSLRRGGVLVYSTCTLSYEENEGNVKFMIRKGMKLEEQSIF
IGSPGIGMNKVQRFYPHKHLTQGFFIAKLRKVKD
3D structure
PDB5zvh Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG B A209 A210 A211 P212 G214 K215 D233 K234 R238 D260 A261 D277 Y304 F308 A205 A206 A207 P208 G210 K211 D229 K230 R234 D256 A257 D273 Y300 F304
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016428 tRNA (cytidine-5-)-methyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0001510 RNA methylation
GO:0006396 RNA processing
GO:0006400 tRNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5zvh, PDBe:5zvh, PDBj:5zvh
PDBsum5zvh
PubMed30541086
UniProtO57712|NSUN6_PYRHO tRNA (cytosine(72)-C(5))-methyltransferase (Gene Name=PH1991)

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