Structure of PDB 5zva Chain B

Receptor sequence
>5zvaB (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
YFQGSAMDPPTFTFNFNNEPWVRGRHETYLCFTMEVVKHHSPVSWKRGVF
RNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVA
EFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKY
CWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
3D structure
PDB5zva Crystal Structure of Cytidine Deaminase Human APOBEC3F Chimeric Catalytic Domain in Complex with DNA
ChainB
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B W-9 V-8 H-4 W277 Y307 Y308 W310 W21 V22 H26 W89 Y119 Y120 W122 PDBbind-CN: Kd=54.86uM
BS02 ZN B H249 C280 C283 H61 C92 C95
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5zva, PDBe:5zva, PDBj:5zva
PDBsum5zva
PubMed
UniProtQ8IUX4|ABC3F_HUMAN DNA dC->dU-editing enzyme APOBEC-3F (Gene Name=APOBEC3F);
Q9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

[Back to BioLiP]