Structure of PDB 5zv2 Chain B

Receptor sequence
>5zv2B (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
SSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVT
KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYV
IVEYASKGNLREYLQARRPEEQLSSKDLVSCAYQVARGMEYLASKKCIHR
DLAARNVLVTEDNVMKIADFGLDYYKKTRLPVKWMAPEALFDRIYTHQSD
VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ
3D structure
PDB5zv2 Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models.
ChainB
Resolution2.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 R627 N628 D641
Catalytic site (residue number reindexed from 1) D151 R155 N156 D169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LEV B L484 G485 F489 A512 E531 M535 V561 Y563 A564 L630 L25 G26 F30 A53 E72 M76 V102 Y104 A105 L158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5zv2, PDBe:5zv2, PDBj:5zv2
PDBsum5zv2
PubMed29733511
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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