Structure of PDB 5zsm Chain B

Receptor sequence

>5zsmB (length=776) Species: 9544 (Macaca mulatta)

ARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH
IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGL
TYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEI
LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST
LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL
AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILR
IRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI
DLSVNKISPQVLEQLYYFRYDKYARSCRFKSCYKYGQTLDLSKNSIFFIK
SSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHS
TAFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDIS
SSTSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISK
NSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHN
QLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKI
QMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLA
TDVTCVGPGAHKGQSVISLDLYTCEL

3D structure

• PDB: 5zsm To be published
• Chain: B
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	H630 D632 R636	H571 D573 R577
BS02	rna	B	I74 H76 R97 C98 L105 S107 D135 E156 Q181 Y184 R186 R467 Y468 D469 A472 R473 S474 C475 R476	I48 H50 R71 C72 L79 S81 D109 E130 Q155 Y158 R160 R419 Y420 D421 A424 R425 S426 C427 R428
BS03	9K9	B	Y264 F351 Q354 Y356 F408	Y238 F325 Q328 Y330 F382
BS04	9K9	B	T532 D555 L557 I585 T586	T473 D496 L498 I526 T527

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5zsm, PDBe:5zsm, PDBj:5zsm
• PDBsum: 5zsm
• PubMed: 30566863
• UniProt: B3Y653