Structure of PDB 5zqu Chain B

Receptor sequence
>5zquB (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
PNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLI
ASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPE
QPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP
3D structure
PDB5zqu Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor alpha (RXR alpha ).
ChainB
Resolution2.60039 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9HF B I268 A272 Q275 L326 F438 F439 I8 A12 Q15 L66 F178 F179 BindingDB: EC50=143nM
BS02 9HF B L436 F439 L176 F179 BindingDB: EC50=143nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5zqu, PDBe:5zqu, PDBj:5zqu
PDBsum5zqu
PubMed30565665
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

[Back to BioLiP]