Structure of PDB 5zqk Chain B

Receptor sequence
>5zqkB (length=875) Species: 11060 (dengue virus type 2) [Search protein sequence]
ETLGEKWKNRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVS
RGSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVKEVKGLTKG
GPGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTV
EAGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMEALQRKYGGALV
RNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDV
DLGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYH
GSYETKQTGSASSMVNGVVRLLTKPWDVIPMVTQMAMTDTTPFGQQRVFK
EKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSN
AALGAIFTDENKWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMG
KREKKLGGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVE
GEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHME
GEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYG
LNTFTNMEAQLIRQMEGEGVFKSIQQLTATEEIAVKNWLVRVGRERLSRM
AISGDDCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPF
CSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSY
AQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTED
MLTVWNRVWIQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRAT
WAKNIQTAINQVRSLIGNEEYTDYM
3D structure
PDB5zqk NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B S56 G81 G86 W87 T104 K105 H110 V130 D131 V132 F133 D146 S50 G75 G80 W81 T98 K99 H104 V124 D125 V126 F127 D140
BS02 MG B D534 D664 D526 D656
BS03 MG B D534 P707 D526 P699
BS04 ZN B E438 H442 C447 C450 E432 H436 C441 C444
BS05 ZN B H712 H714 C728 C847 H704 H706 C720 C839
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5zqk, PDBe:5zqk, PDBj:5zqk
PDBsum5zqk
PubMed31597763
UniProtH9M652

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