Structure of PDB 5zob Chain B

Receptor sequence
>5zobB (length=156) Species: 64320 (Zika virus) [Search protein sequence]
KGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGR
LDPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPG
IFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSA
ITQGKR
3D structure
PDB5zob Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H51 D129 Y130 A132 G133 S135 G151 G153 Y161 H37 D115 Y116 A118 G119 S121 G137 G139 Y147
BS02 peptide B V36 H51 S135 V22 H37 S121
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5zob, PDBe:5zob, PDBj:5zob
PDBsum5zob
PubMed30315877
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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