Structure of PDB 5zmc Chain B

Receptor sequence
>5zmcB (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
SGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNK
PKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHA
MLDVKP
3D structure
PDB5zmc Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.
ChainB
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y386 R391 R394 Y397 K404 R409 Y410 Y55 R60 R63 Y66 K73 R78 Y79
BS02 dna B Q336 L337 W375 K388 R391 Y395 Y396 Q5 L6 W44 K57 R60 Y64 Y65
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:5zmc, PDBe:5zmc, PDBj:5zmc
PDBsum5zmc
PubMed30093619
UniProtP14921|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

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