Structure of PDB 5zkj Chain B

Receptor sequence
>5zkjB (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
SAEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMG
DADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMA
ETFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTR
GDGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEA
IGFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQ
EFTLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELK
AKE
3D structure
PDB5zkj A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
ChainB
Resolution2.798 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C57 A85 N107 N116 E124
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R109 K110 S137 R138 G139 A140 A144 G145 K148 F168 N171 S172 N176 L311 R314 R54 K55 S82 R83 G84 A85 A89 G90 K93 F113 N116 S117 N121 L256 R259 PDBbind-CN: Kd=0.19uM
BS02 dna B K115 S172 L311 K315 R320 K60 S117 L256 K260 R265 PDBbind-CN: Kd=0.19uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5zkj, PDBe:5zkj, PDBj:5zkj
PDBsum5zkj
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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