Structure of PDB 5zki Chain B

Receptor sequence
>5zkiB (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
AEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGD
ADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAE
TFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRG
DGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAI
GFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQE
FTLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKA
KEQS
3D structure
PDB5zki A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
ChainB
Resolution2.321 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C56 A84 N106 N115 E123
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R109 S137 R138 G139 A140 A144 G145 F168 N171 S172 N176 L311 R314 R53 S81 R82 G83 A84 A88 G89 F112 N115 S116 N120 L255 R258 PDBbind-CN: Kd=1.32uM
BS02 dna B K113 S172 L311 K315 R320 R324 K57 S116 L255 K259 R264 R268 PDBbind-CN: Kd=1.32uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5zki, PDBe:5zki, PDBj:5zki
PDBsum5zki
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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