Structure of PDB 5zk7 Chain B

Receptor sequence
>5zk7B (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]
EHYIKHPLQNRWALWFFKNDWQANLRLISKFDTVEDFWALYNHIQLSSNL
MPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLL
CLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKE
RLGLPPKIVIGYQSHADTAKNRFVV
3D structure
PDB5zk7 Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
ChainB
Resolution2.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H37 P38 L39 Q40 V69 W73 N77 E132 G139 R186 H6 P7 L8 Q9 V34 W38 N42 E97 G104 R151
BS02 peptide B R128 L131 R93 L96
BS03 MGT B W56 M101 W102 E103 R157 W21 M66 W67 E68 R122
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zk7, PDBe:5zk7, PDBj:5zk7
PDBsum5zk7
PubMed30881679
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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