Structure of PDB 5zeh Chain B

Receptor sequence
>5zehB (length=293) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
QSMQFEKVTYIAVPQKYGQKKVGVEEGPKFLEKLGFMNVLEQVAKSVNKK
TITEPKTPQETNARNLNEVESVNIELRDTIAKEYDVNNLLINIGGDHSIG
LGTIAGVVKAMKPNARVGVVWFDAHPDMNTPENSPSGNIHGMPLACAVGL
GPQRLTSIMPHYITPKDIMYVGIRSIDVGEQFEIQDKHIDHFTAEDVKRV
GMKEVIEAINKKFVDYDVIHLSFDIDGIDPEFILGTGTPVPKGISLEDSL
YFMSEMGKMKKLHSVDIVEYNPKIEEEITGKNVLKCISSLFGI
3D structure
PDB5zeh Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
ChainB
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.1: arginase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ORN B H126 N130 S137 H141 H125 N129 S136 H140
BS02 MN B H98 D124 D128 D225 H97 D123 D127 D224
BS03 MN B D124 H126 D225 D227 D123 H125 D224 D226
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000050 urea cycle
GO:0006525 arginine metabolic process
GO:0019547 arginine catabolic process to ornithine
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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External links
PDB RCSB:5zeh, PDBe:5zeh, PDBj:5zeh
PDBsum5zeh
PubMed31199070
UniProtC4LSS0|ARGI_ENTH1 Arginase (Gene Name=ARG)

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