Structure of PDB 5zb0 Chain B

Receptor sequence
>5zb0B (length=183) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
GLFLTLEGLDGSGKTTQARRLAAFLEAQGRPVLLTREPGGGLPEVRSLLL
TQELSPEAEYLLFSADRAEHVRKVILPGLAAGKVVISDRYLDSSLAYQGY
GRGLPLPWLREVAREATRGLKPRLTFLLDLPPEAALGLEFFRRVREGYLA
LARAEPGRFVVLDATLPEEEIARAIQAHLRPLL
3D structure
PDB5zb0 Insights into product release dynamics through structural analyses of thymidylate kinase.
ChainB
Resolution1.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYD B E39 P40 R48 F65 R69 R91 S95 S96 Y99 Q100 E37 P38 R46 F63 R67 R89 S93 S94 Y97 Q98
BS02 ADP B D12 G13 G15 K16 T17 T18 L138 E182 D10 G11 G13 K14 T15 T16 L136 E168
BS03 MG B T7 E9 D94 T5 E7 D92
BS04 MG B P40 F65 D68 P38 F63 D66
BS05 MG B Y62 S66 R69 Y60 S64 R67
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:5zb0, PDBe:5zb0, PDBj:5zb0
PDBsum5zb0
PubMed30447376
UniProtQ5SHX3|KTHY_THET8 Thymidylate kinase (Gene Name=tmk)

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