Structure of PDB 5z4h Chain B

Receptor sequence
>5z4hB (length=190) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHA
DNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGVGVSVVNALSQKLE
LVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTE
FEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGG
3D structure
PDB5z4h Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AX7 B H147 E174 H116 E143
BS02 A8K B V43 N46 A47 Q72 D73 I78 A91 I94 M95 V120 T165 V167 V28 N31 A32 Q57 D58 I63 A76 I79 M80 V89 T134 V136
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5z4h, PDBe:5z4h, PDBj:5z4h
PDBsum5z4h
PubMed30429968
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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