Structure of PDB 5z2c Chain B

Receptor sequence
>5z2cB (length=445) Species: 9606 (Homo sapiens) [Search protein sequence]
NNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLI
QEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILA
RDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQ
ARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRG
QILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSK
NDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVN
IRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQEL
HSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDR
EALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLIL
3D structure
PDB5z2c Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
ChainB
Resolution2.594 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AYU B F61 Q67 R116 Y119 Q146 R150 R153 V195 Q198 Y224 D231 K233 G234 S236 T237 F295 F60 Q66 R115 Y118 Q145 R149 R152 V194 Q197 Y223 D230 K232 G233 S235 T236 F294
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:5z2c, PDBe:5z2c, PDBj:5z2c
PDBsum5z2c
PubMed30111836
UniProtQ96QP1|ALPK1_HUMAN Alpha-protein kinase 1 (Gene Name=ALPK1)

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