Structure of PDB 5yxj Chain B

Receptor sequence
>5yxjB (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATN
HVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKHSDLL
EERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYI
KDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHA
EMLMSWRHKFTPLLCEIWDV
3D structure
PDB5yxj A ligand of drug binding to FXR
ChainB
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K303 H313 Q316 K321 K60 H70 Q73 K78
BS02 93U B H294 M328 F329 S332 I357 Y361 H447 M450 W454 W469 H51 M85 F86 S89 I109 Y113 H199 M202 W206 W218
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5yxj, PDBe:5yxj, PDBj:5yxj
PDBsum5yxj
PubMed
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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