Structure of PDB 5ywt Chain B

Receptor sequence
>5ywtB (length=220) Species: 10090 (Mus musculus) [Search protein sequence]
HGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPV
PRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAIL
LRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIA
ALKALEQRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALL
QWVDEHARPFSTVKPMYGTP
3D structure
PDB5ywt Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E20 A21 G23 L24 I84 H124 N125 Y129 S176 Y177 S178 L179 H195 E13 A14 G16 L17 I77 H117 N118 Y122 S160 Y161 S162 L163 H179
BS02 MG B D18 E20 D200 D11 E13 D184
BS03 CO B S78 P79 G80 S71 P72 G73
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5ywt, PDBe:5ywt, PDBj:5ywt
PDBsum5ywt
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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