Structure of PDB 5ywd Chain B

Receptor sequence
>5ywdB (length=1154) Species: 10036 (Mesocricetus auratus) [Search protein sequence]
GVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNY
QRLCVAFDAQARKGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLC
IFGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQT
KIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPV
QIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSN
ERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSIS
IFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLL
SSVVRSTVKALVSVQKLSEFLSSAEIREECVQIIGGFFTWTPDGIPTLSN
ITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWGPVAYASQK
PWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGER
GINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILEL
LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSERACTK
YLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLC
SLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL
NRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLA
VVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEAR
FQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSL
HRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTE
AESYEGPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKI
GICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSII
LQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAII
TEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVM
TAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFA
SFVR
3D structure
PDB5ywd Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
ChainB
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B W688 G716 G718 K719 S720 S721 Q775 E1480 S1483 W390 G418 G420 K421 S422 S423 Q449 E1055 S1058
BS02 ADP B E1114 Y1354 G1382 G1384 K1385 S1386 S1387 E692 Y929 G957 G959 K960 S961 S962
BS03 MG B S720 Q775 S422 Q449
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0043531 ADP binding
GO:0044325 transmembrane transporter binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0001508 action potential
GO:0006813 potassium ion transport
GO:0031669 cellular response to nutrient levels
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0046676 negative regulation of insulin secretion
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0061535 glutamate secretion, neurotransmission
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0098793 presynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ywd, PDBe:5ywd, PDBj:5ywd
PDBsum5ywd
PubMed29594720
UniProtA0A1U7R319

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