Structure of PDB 5yvg Chain B

Receptor sequence
>5yvgB (length=764) Species: 9606 (Homo sapiens) [Search protein sequence]
GLQQILQLLKESQSPDTTIQRTVQQKLEQLNLIFVLTKLKSEDEPTRSLS
GLILKNNVKAHFGVTDFIKSECLNNIGDSSPLIRATVGILITTIAWPDLL
PKLCSLLDCEGAFGALQKICEDSAEILNIMIPKFLQFFPKIRSHAVACVN
QFILHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVLPHMHNIVEYML
QRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSD
IDIILSDWNLRKCSAAALDVLANVLPHILPLLKELLFHHEWVVKESGILV
LGAIAMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQP
PDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYIL
DTLVFAFSKYQHKNLLILYDAIGTLADSVLNKPEYIQMLMPPLIQKWNML
KDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLN
NAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCM
QDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCN
NATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIG
RLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPS
GVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQF
PLPLKERLAAFYGV
3D structure
PDB5yvg Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
ChainB
Resolution4.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K377 E498 S502 I540 D543 K262 E375 S379 I417 D420
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport

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Molecular Function
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Biological Process
External links
PDB RCSB:5yvg, PDBe:5yvg, PDBj:5yvg
PDBsum5yvg
PubMed29677513
UniProtQ92973|TNPO1_HUMAN Transportin-1 (Gene Name=TNPO1)

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