Structure of PDB 5yt3 Chain B

Receptor sequence
>5yt3B (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
LELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKP
SGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEI
SICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR
DVKPSNILVNSRGEIKLCDFGVSGQLIDDMANDFVGTRSYMSPERLQGTH
YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGAIFELLDYIVNEP
PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDF
AGWLCSTIGLN
3D structure
PDB5yt3 Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 N195 D208 D217 T226
Catalytic site (residue number reindexed from 1) D151 K153 N156 D169 D178 T187
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B L74 G75 A76 G77 N78 G79 V82 A95 K97 M146 S150 Q153 K192 S194 N195 L197 L35 G36 A37 G38 N39 G40 V43 A56 K58 M107 S111 Q114 K153 S155 N156 L158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5yt3, PDBe:5yt3, PDBj:5yt3
PDBsum5yt3
PubMed
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

[Back to BioLiP]